The Centre of Experimental Medicine (CEM) of the Slovak Academy of Sciences (SAS) was established on 1 January 2018 by merging of the Institute of Experimental Pharmacology and Toxicology, the Institute of Normal and Pathological Physiology and the Institute of Heart Research into one Centre. CEM is focused on the integrated research into the causes, mechanisms of development and possibilities of prevention, diagnosis and treatment of societally important diseases with the emphasis on diseases of the cardiovascular and the nervous systems, metabolic disorders, mental disorders and mental health problems as well as diseases originating in the prenatal and early postnatal developmental periods. The research in CEM is carried out on in silico, in vitro, ex vivo and in vivo models with the aim to transfer the acquired knowledge to clinical practice. An important part is the evaluation of the effects of bioactive natural substances, their derivatives and original synthetic substances with pharmacotherapeutic potential, animal models of human diseases as well as the study of side-effects of toxic and chemical agents and radiation.
